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By Shutsung Liao, John M. Kokontis, Chih-Pin Chuu, Richard A. Hiipakka (auth.), James Mohler, Donald Tindall (eds.)

ISBN-10: 0387691774

ISBN-13: 9780387691770

ISBN-10: 0387691790

ISBN-13: 9780387691794

This e-book serves as a tribute to the paintings of the various investigators who've tried to appreciate the position of the androgen receptor (AR) within the improvement and development of prostate melanoma. the connection among prostate melanoma and androgen prestige was once first and foremost preferred within the overdue 1800’s, after which understanding reawakened within the 1940’s via the stories of Charles Huggins and co-workers, for which the Nobel prize was once provided in 1966.

The goal of this e-book is to supply an up-to-the-minute evaluation of the molecular and mobile points of androgen motion in prostate melanoma. It contains an outline of the position of androgens within the improvement of the traditional prostate and development of prostate melanoma. Our figuring out of androgen metabolism and efforts to focus on androgen metabolism within the prevention and remedy of prostate melanoma is gifted. Androgen receptor structure/function relationships and the function of co-regulators are outlined. Ligand-independent activation of the androgen receptor and the function of the androgen receptor in the course of development to the castration recurrent phenotype are mentioned. Androgen-regulated genes are elucidated and their roles in the course of prostate melanoma development are outlined. eventually, the androgen receptor is gifted as a workable aim for novel cures. jointly, those experiences should still supply the reader a finished conceptual framework of androgen motion in prostate cancer.

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Interactions between these helices are important for coactivator recruitment and the mutation may influence binding of coactivators and modulate their effects on transcription (McDonald et al. 2000). 1 Autoantibodies to AR in Prostate Cancer Patients Jensen and colleagues were the first to obtain antibodies against a steroid receptor by immunization of rabbits with estrogen receptor isolated from a very large quantity of calf uteri (Greene et al. 1977). Similar attempts by our group to isolate enough AR for immunization were not successful.

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Androgen Action in Prostate Cancer by Shutsung Liao, John M. Kokontis, Chih-Pin Chuu, Richard A. Hiipakka (auth.), James Mohler, Donald Tindall (eds.)


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