Anesthesia and Analgesia in Laboratory Animals (American by Dennis F. Kohn, Sally K. Wixson, William J. White, G. John PDF

By Dennis F. Kohn, Sally K. Wixson, William J. White, G. John Benson

ISBN-10: 0080527221

ISBN-13: 9780080527222

ISBN-10: 0124175708

ISBN-13: 9780124175709

Anesthesia and Analgesia in Laboratory Animals focuses fullyyt at the designated anesthetic, analgesic, and postoperative care standards linked to experimental surgical procedure. subsidized via the yank collage of Laboratory Animal drugs, this informative paintings presents the reader with brokers, tools, and methods for anesthesia and analgesia that confirm humane and profitable procedural results. Key positive factors* makes a speciality of a wide selection of animal species utilized in examine* offers a complete evaluation of the pharmacology of anesthetics and analgesics* comprises tracking of analgesia and anesthesia* Organizes issues through species for brokers and techniques of offering anesthesia, analgesia, and post-op care to animals* No different American textual content is dedicated completely to this subject

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Extra resources for Anesthesia and Analgesia in Laboratory Animals (American College of Laboratory Animal Medicine Series)

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Pharmacologic B. Mechanism of Action Central noradrenergic neurotransmission is potently decreased by ct2-agonists, but neither the hypnotic-anesthetic nor the analgesic effect is explained by this action alone. The mechanism involves a pertussis-sensitive guanine nucleotide-binding (G) protein and a 4-aminopyridine-sensitive ion channel (Daunt and Maze, 1992; Maze and Regan, 1991). , 1989; Virtanen, 1986). Inhibition of noradrenergic neurons in the locus coeruleus by %-agonists may explain sedative effects, as these neurons are Effects As in most species, xylazine alone in mice does not produce sleep or loss of the righting reflex (Hsu, 1992).

1964) and increases plasma prolactin (Booth, 1988c). 2. Azaperone Azaperone in the rat has been characterized as a sedative neuroleptic. Conditioned and exploratory behaviors are inhib- Fluanisone Fluanisone is used most commonly in combination with fentanyl as a neuroleptanalgesic (Hypnorm; see Section IX). C. Benzodiazepine Derivatives 1. Description A variety of benzodiazepines are used in human medicine for their sedative, hypnotic, anxiolytic, skeletal muscle relaxant, and anticonvulsant properties.

A. Description D. Pharmacologic Effects Anesthetic effects of steroids have been recognized since the 1940s (Sutton, 1972). Currently, Saffan or Althesin, a Alphaxalone-alphadolone has anticonvulsant effects in rat models of epilepsy, but only at hypnotic/anesthetic doses. This 12 R I C H A R D E. F I S H pattern resembles that of pentobarbital and supports the view that steroids and barbiturates have similar mechanisms of action (Peterson, 1989). In contrast to anticonvulsant effects, a high incidence of myoclonic jerks occurs in mice following alphaxalone/alphadolone administration (File and Simmonds, 1988).

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Anesthesia and Analgesia in Laboratory Animals (American College of Laboratory Animal Medicine Series) by Dennis F. Kohn, Sally K. Wixson, William J. White, G. John Benson

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