By Priv.-Doz. Dr. Christian Birr (auth.)
This ebook used to be written within the context of the day-by-day disagreement with difficulties within the usage of polymeric helps for the synthesis of pep tides. consequently, perspectives and studies which typically aren't pointed out in medical journals are accumulated in those pages. the writer has intentionally mentioned intimately the potential impact of the polymer part at the various response stipulations within the Merrifield synthesis; this element is ignored in so much courses facing peptide synthesis. in spite of the fact that, in view of the growing to be physique of data at the chemistry of polymer-supported peptide syntheses, the overseas readership should still regard the author's arguments as open to dialogue. i'm a great deal indebted to all of my colleagues with whom i've got had the chance to cooperate in learning the possibility of the Merrifield synthesis. principally i admire to precise my gratitude to my instructor, Professor Dr. Theodor Wieland, Heidelberg, for his boundless encouragement and help in my ef forts within the box of peptide synthesis, rather in its polymer part sure model. final yet no longer no less than I desire to thank leave out Hildegard Leyden. With in finite persistence and nice accuracy she typed the manuscript as well as her day-by-day tasks. The paintings which stimulated this e-book was once played below the auspices of the Max-Planck-Gesellschaft, of which the monetary aid is gratefully ac knowledged.
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Extra info for Aspects of the Merrifield Peptide Synthesis
In general, it is very delicate to wash those polar molecules completely out of a lipophilic polymer tracery. e) The determination of functional sites like primary amino groups on polymer - to measure the yield of attachment by deprotection of an amino acyl moiety bound to the support - by an additional chemical reaction for analysis is a widely used but net always critically judged testing method. Doubtless, the titration as described on the preceding page of a hydrochloride formed with amino functions  is an accurate measure as long as no halogen-containing solvents were used in preceding washings of the polymer support.
Wash-out of cleavage product _14 repetition Ddz cleavage _'4 60 Fig. 39.
To prepare the protected amino acids, Ddz-prestages like -hydrazide and -azide, both crystalline and absolutely nonexplosive, are commercially available . In addition, a number of suitably protected trifunctional Ddz-amino acids are produced comparable in price to the Boc-derivatives formerly used . Not only because of its moderate lability, the Ddz-group is particularly useful in the practice of the Merrifield synthesis. As only briefly indicated on p. 35, the spectroscopical properties of this masking residue allow the continuous control of the whole Merrifield procedure by flow photometry in addition to quantitative load measurements and detections of completed reactions on gel phase [95, 103].
Aspects of the Merrifield Peptide Synthesis by Priv.-Doz. Dr. Christian Birr (auth.)