By J. R. Tata (auth.), Robert F. Goldberger, Keith R. Yamamoto (eds.)
The motivation for us to conceive this sequence of volumes on rules was once usually our trust that it might be enjoyable, and whilst effective, to technique the topic in a fashion that differs from that of alternative treatises. We notion it'd be attention-grabbing and instructive for either writer and reader-to study a specific quarter of research in a framework of many alternative difficulties. slicing around the conventional barriers that experience separated the topics in earlier volumes on legislation isn't really a simple factor to do-not since it is tough to think about what attention-grabbing subject matters may still exchange the previous ones, yet since it is tough to discover authors who're keen to put in writing approximately components open air these pursued of their personal laboratories. a person who takes at the activity of reviewing a extensive niche needs to weave jointly its numerous elements through deciding upon up the threads from many alternative laboratories, and try to produce a material with a significant layout. discovering individuals who're more likely to reach one of these activity used to be the main tricky a part of our activity. within the first quantity of this treatise, many of the chapters handled the mechanisms of the second one quantity concerned a just a little law of gene expression in microorganisms. broader zone, spanning the prokaryotic-eukaryotic border. themes ranged from phage mor phogenesis to the position of gradients in improvement. The final volume-Volume 3A-con cerned hormones, as does this volume-Volume 3B.
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Extra info for Biological Regulation and Development: Hormone Action
1978). Many characteristics of the cytoplasmic-nuclear receptor translocation are consistent with the hormonal effects on transcription, or ultimately on growth and development. These include hormonal specificity, duration of lag period preceding the response, differences between primary and secondary responses, and effects of hormone agonists and antagonists. , 1978; Oppenheimer and Dillmann, 1978; Samuels, 1978; Oppenheimer, 1979; Tata, 1980b) and therefore lacks a distinct cytoplasm-nucleus translocation step.
R. , 1982; see Chapter 2, this volume). Down-regulation might serve to protect the target cell from excessive or uncontrolled hormonal stimulation, and may involve both reduction in receptor number and alteration of hormone binding properties. " Clark et al. (1972) suggested that marked fluctuations of nuclear estrogen receptor levels in the rat uterus during the estrous cycle may be of physiological significance and under the control of endogenous estrogen. Similarly, estrogen administration and withdrawal are accompanied by a modest and reversible increase in receptor level in the immature chick oviduct that parallels hormonal induction of egg white protein synthesis (Sutherland and Baulieu, 1976; Mulvihill and Palmiter, 1977).
2 Autoregulation of Receptors Whereas the acquisition of receptors during differentiation of the target cells appears to be autonomous, modulation of receptor activity in differentiated cells is often under hormonal control. In many instances a hormone can regulate the level of its own receptor. Perhaps the first well-documented example of such autoregulation was provided by the phenomenon of "down-regulation" of plasma membrane receptors for insulin and other peptide hormones (Hinkle and Tashjian, 1975; Kahn, 1976; Catt and Dufau, 1977, 1978; Kaplan, 1981).
Biological Regulation and Development: Hormone Action by J. R. Tata (auth.), Robert F. Goldberger, Keith R. Yamamoto (eds.)