Black Science 010 (2014) (digital) (Son of Ultron-Empire) - download pdf or read online

By Rick Remender

Fueled via a protracted string of disasters as a pace-setter, Kadir launches a mad rescue test. Can he dwell as much as his promise and at last redeem himself, or will he fall underneath the crawling chaos of 1000000 psychic millipedes?

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Extra info for Black Science 010 (2014) (digital) (Son of Ultron-Empire)

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1978). Many characteristics of the cytoplasmic-nuclear receptor translocation are consistent with the hormonal effects on transcription, or ultimately on growth and development. These include hormonal specificity, duration of lag period preceding the response, differences between primary and secondary responses, and effects of hormone agonists and antagonists. , 1978; Oppenheimer and Dillmann, 1978; Samuels, 1978; Oppenheimer, 1979; Tata, 1980b) and therefore lacks a distinct cytoplasm-nucleus translocation step.

R. , 1982; see Chapter 2, this volume). Down-regulation might serve to protect the target cell from excessive or uncontrolled hormonal stimulation, and may involve both reduction in receptor number and alteration of hormone binding properties. " Clark et al. (1972) suggested that marked fluctuations of nuclear estrogen receptor levels in the rat uterus during the estrous cycle may be of physiological significance and under the control of endogenous estrogen. Similarly, estrogen administration and withdrawal are accompanied by a modest and reversible increase in receptor level in the immature chick oviduct that parallels hormonal induction of egg white protein synthesis (Sutherland and Baulieu, 1976; Mulvihill and Palmiter, 1977).

2 Autoregulation of Receptors Whereas the acquisition of receptors during differentiation of the target cells appears to be autonomous, modulation of receptor activity in differentiated cells is often under hormonal control. In many instances a hormone can regulate the level of its own receptor. Perhaps the first well-documented example of such autoregulation was provided by the phenomenon of "down-regulation" of plasma membrane receptors for insulin and other peptide hormones (Hinkle and Tashjian, 1975; Kahn, 1976; Catt and Dufau, 1977, 1978; Kaplan, 1981).

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Black Science 010 (2014) (digital) (Son of Ultron-Empire) by Rick Remender

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